Autologous bone marrow mononuclear cell administration for neurological sequelae after traumatic brain injury: a matched control study.

ABSTRACT: Neurological sequelae after traumatic brain injury impair motor and behavioural functions, imposing a heavy burden on patients and society. Traditional treatments show limited efficacy, highlighting the need for advanced therapies. This study evaluated the safety and efficacy of intrathecal administration of bone marrow mononuclear cells for treating these sequelae. A matched control clinical trial was conducted on 50 patients. The intervention group received two intrathecal infusions of bone marrow mononuclear cells, 6 months apart, combined with rehabilitation therapy, while the control group received rehabilitation therapy only. Safety was assessed through adverse events and serious adverse events. Effectiveness was measured via the Functional Independence Measure, Short Form-36 Quality

SUBMITTER: Nguyen LT 

PROVIDER: S-EPMC12501777 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature