Association between higher estimated glucose disposal rate and reduced prevalence of hyperuricemia and gout.

ABSTRACT:

Objective

Insulin resistance (IR) is closely associated with hyperuricemia (HUA) and gout; however, the relationship between the estimated glucose disposal rate (eGDR), a novel comprehensive indicator of systemic IR, and the prevalence of HUA and gout in the general population remains unclear.

Methods

This study analyzed data from 29,340 participants included in the National Health and Nutrition Examination Survey (NHANES) database. Multivariable logistic regression models and restricted cubic splines were employed to assess the association between eGDR and HUA and gout. Subgroup analyses were conducted to examine potential variations in the findings across different subgroups stratified by age, sex, race, and diabetes status.

Results

The prevalence rates of HUA and g

SUBMITTER: Liu P 

PROVIDER: S-EPMC12501789 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature