Risk of Parkinson Disease Among Patients With Restless Leg Syndrome.

ABSTRACT:

Importance

The association between restless leg syndrome (RLS) and Parkinson disease (PD) remains unclear. Clarifying this association and the role of the dopaminergic pathway may improve understanding of the pathophysiology between these 2 diseases.

Objectives

To assess whether RLS is a risk factor for developing PD and whether the dopamine pathway is meaningfully associated with RLS and PD.

Design, setting, and participants

This retrospective cohort study used data from the Korean National Health Insurance Service Sample Cohort from 2002 to 2019. Statistical analyses were performed between September 2024 and March 2025. Patients with RLS and PD were identified based on codes from the International Statistical Classification of Diseases and Related Health Problems, T

SUBMITTER: Bang M 

PROVIDER: S-EPMC12501809 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature