Evaluation of the multiple HPV-based "screen and triage" algorithms in real-world settings of rural China.

ABSTRACT:

Objective

Drawbacks of human papillomavirus (HPV) primary screening, including high referral rates and low specificity, highlight the necessity for triage strategies to balance the screening benefits with potential harms.

Methods

A cross-sectional, population-based diagnostic study was conducted in rural Xinjiang, China involving 8,638 women ≥ 25 years of age who participated in organized cervical cancer screening between 2023 and 2024. The study evaluated the accuracy and efficiency of multiple HPV-based "screen-triage" strategies. Histologically confirmed cervical intraepithelial neoplasia grade 2 or worse (CIN2+ and CIN3+) served as disease outcomes.

Results

Among single-step triage strategies, only extended genotyping for the seven most carcinogenic HPV types (HPV

SUBMITTER: Rezhake R 

PROVIDER: S-EPMC12501896 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature