Conversion Therapy for Locally Advanced Intrahepatic Cholangiocarcinoma: A Retrospective Cohort Study.

ABSTRACT:

Background and objectives

Intrahepatic cholangiocarcinoma (iCCA) is a highly malignant biliary tumor associated with a poor prognosis. Here, we explored conversion therapy (CT) for the treatment of locally advanced iCCA (LA-iCCA).

Methods

We retrospectively enrolled 115 patients with LA-iCCA at our single center from January 2019 to June 2024, with the final follow-up conducted in January 2025. The primary outcome measured was overall survival (OS), while the secondary outcome focused on progression-free survival (PFS). We utilized a propensity score matching (PSM) approach to adjust for potential confounders between the CT group and the systemic therapy (ST) group.

Results

Before PSM, the median OS was 34.57 months (95% CI: 19.22-49.91), while the median PFS was 17.3

SUBMITTER: Lu J 

PROVIDER: S-EPMC12501912 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature