P53 Function Status Correlates With Overall Survival in Patients With Resected Pancreatic Cancer.

ABSTRACT:

Background

The P53 gene is the most common tumor-suppressor gene mutated in pancreatic ductal adenocarcinoma (PDAC). The gene's normal function is critical for regulation of replication, DNA repair, and apoptosis. The purpose of our study is to determine the impact of the various P53 mutation subtypes on survival in resected PDAC.

Methods

This is a retrospective cohort study assessing patients that underwent curative-intent resection for PDAC between the years of 2016-2022. Next generation sequencing (NGS) was performed on patient tumors. P53 tumor genotypes were grouped into wild-type (WT), gain-of-function (GOF) mutations (R175H, R248W, R248Q, R273H, R282W, G245S) and all other non-GOF mutations.

Results

The study included a total of 330 patients with resected PDAC.

SUBMITTER: Chen H 

PROVIDER: S-EPMC12501923 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature