Terpenes as Naturally Occurring Stereochemical Templates: Conformationally Driven Discovery of Reactivity.

ABSTRACT: Natural terpene-derived substrates have been used as stereochemical templates in the gold(I)-catalyzed cycloisomerization of aliphatic 1-bromoalkynes. The conformational restrictions imposed by these substrates have unlocked an unprecedented 5-exo cyclization mode in gold catalysis. This reactivity was extended to structurally simplified substrates.

SUBMITTER: Arto O 

PROVIDER: S-EPMC12501937 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature