Music elicits different gene expression responses in the buccal cavity of age-related cognitive disorders patients and healthy controls.

ABSTRACT:

Introduction

Recent evidence suggests that external stimuli can shape transcriptomes, a field emerging as sensogenomics. Specifically, the analysis of capillary blood samples has shown that musical stimuli can modulate gene expression patterns, not only in healthy individuals but also in those with age-related cognitive disorders (ACD).

Methods

Using targeted transcriptomics with Nanostring nCounter, we present groundbreaking evidence indicating that brief exposure to music can also impact the buccal transcriptome in both healthy donors and ACD patients.

Results

Our findings reveal that music elicits stronger transcriptomic effect on patients compared to controls, driving global upregulation in ACD patients but downregulation in controls. The most significantly dysreg

SUBMITTER: Gomez-Carballa A 

PROVIDER: S-EPMC12501983 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature