Uric acid as a potential biomarker for cardiomyopathy in dystrophinopathy.

ABSTRACT:

Background

Cardiomyopathy is a significant cause of mortality in dystrophinopathy, and early detection and intervention are critical to reduce the disease burden. Currently, cardiomyopathy detection primarily relies on echocardiography and cardiac magnetic resonance imaging (CMR), which are inconvenient for paediatric patients and those in remote areas. Uric acid (UA) is associated with various heart diseases and serves as a biomarker of injury severity, but its level changes and connection with myocardial injury in dystrophic cardiomyopathy remain unclear. Therefore, we investigated the relationship between UA and cardiomyopathy in dystrophinopathy, as its early detection may offer a more straightforward method for monitoring cardiac health.

Method

A total of 71 dystrophino

SUBMITTER: Li Z 

PROVIDER: S-EPMC12502115 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature