Gut microbiota profiles associated with persistent anal HPV infection in men who have sex with men.

ABSTRACT:

Objective

To explore the differences in the composition of the anorectal microbiota in the context of known anorectal HPV infection, providing scientific evidence for early prevention and intervention of persistent HPV infection in the MSM population.

Methods

A retrospective analysis was performed based on an existing prospective cohort study conducted between 2016 and 2023, which provided rectal swab samples for microbiota sequencing. After providing consent, 58 participants with more than 8 months of follow-up were divided into two groups on the basis of their HPV infection status during their last two follow-up visits: the HPV-negative group (negative) and the persistent HPV-positive group (positive). Rectal swab samples were collected from both groups, and 16 S rRNA sequ

SUBMITTER: Yang H 

PROVIDER: S-EPMC12502131 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature