Growth impairment in glycogen storage disease type I versus types III/VI/IX: a cross-sectional study.

ABSTRACT:

Background

Growth retardation is common in glycogen storage disease (GSD), though the relative contributions of hormonal and metabolic factors remain unclear. We compared clinical and biochemical features between GSD I and non-GSD I patients and identified independent predictors of height standard deviation score (SDS).

Methods

Thirty-eight children with GSD (24 with GSD I; 14 with GSD III/VI/IX; mean age: 7.5 years) underwent evaluation of height SDS, BMI SDS, IGF1 SDS, and metabolic parameters. After excluding three patients with inflammatory bowel disease (final n = 35), multiple regression was used to identify factors associated with height SDS. In GSD I (n = 24), Lasso regression selected variables, and 1,000 bootstrap resamples assessed coefficient stability.

Result

SUBMITTER: Wu X 

PROVIDER: S-EPMC12502152 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature