Association between childhood adiposity and gynecologic cancers: a mendelian randomization analysis.

ABSTRACT:

Purpose

The causal relationship between childhood adiposity and gynecologic cancers remains unclear. We performed a two-sample Mendelian randomization (MR) study to elucidate the association between childhood adiposity and the risk of gynecologic cancers.

Methods

The three distinct indicators of childhood adiposity that constitute the exposures were childhood body mass index (CBMI), childhood body size at age 10 (CBS-10) and childhood obesity (COBE). In tandem, the study scrutinized the outcomes encompassing gynecologic cancers, including ovarian cancer (OC), endometrial cancer (EC), cervical cancer (CC) and their subtypes.

Results

The results of the inverse variance weighted (IVW) method suggested that CBMI was positively associated with OC (OR = 1.219, 95% CI, 1.084

SUBMITTER: Zhu M 

PROVIDER: S-EPMC12502270 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature