Endothelial cell-derived apoptotic bodies modulate innate and adaptive immune responses during inflammation.

ABSTRACT: Endothelial cells (ECs) act as gatekeepers and signalling hubs that coordinate communication between blood vessels and surrounding tissues by regulating vascular tone, immune responses and numerous other physiological processes. During vascular inflammation commonly associated with aging, atherosclerosis, diabetes and autoimmunity, a range of biological, environmental and physical stressors can induce activation and apoptosis of ECs. Apoptotic bodies (ApoBDs) are large (~ 1-5 μm), membrane‑bound extracellular vesicles generated solely through apoptotic cell disassembly, that are increasingly recognised as mediators of intercellular communication via the transfer of bioactive molecules to target cells. Although EC apoptosis is a central feature of vascular inflammatory disorders, the format

SUBMITTER: Vella CL 

PROVIDER: S-EPMC12502297 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature