Global prevalence of metabolic dysfunction-associated fatty liver disease in children and adolescents with overweight and obesity: a systematic review and meta-analysis.

ABSTRACT:

Background

The prevalence of Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) among children and adolescents with overweight and/or obesity is rising globally, reflecting increasing obesity rates and metabolic syndrome. This study aims to provide a comprehensive global estimate of MAFLD prevalence in this population.

Methods

A systematic review and meta-analysis were conducted using data from PubMed, Embase, Medline, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science, up to May 10, 2024. We included studies that diagnosed MAFLD in children and adolescents aged 1 to 19 years using histological, imaging, or blood biomarker evidence. The prevalence rates were analyzed, and subgroup analyses were performed based on continent, development sta

SUBMITTER: Jia S 

PROVIDER: S-EPMC12502364 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature