Integrated multi-omics highlights alterations of gut microbiome functions in prodromal and idiopathic Parkinson's disease.

ABSTRACT:

Background

Parkinson's disease (PD) is associated with gut microbiome shifts. These shifts are mainly described at taxonomic level, but the functional consequences remain unclear. To obtain insight into the functional disruptions of the gut microbiome in PD, we used an integrated multi-omics approach, comparing gut microbiomes of individuals with PD, prodromal PD, and healthy controls.

Results

Meta-metabolomics, the most discriminatory and robust omics level, was selected to Guide the analysis. We identified 11 metabolites that were differentially abundant between the groups, among which β-glutamate was increased in PD and prodromal PD, and correlated with the transcriptional activities of Methanobrevibacter smithii and Clostridium spp. We identified decreases in transcripts

SUBMITTER: Villette R 

PROVIDER: S-EPMC12502400 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature