Rabbits as preclinical animal models of cam morphology: proof of concept.

ABSTRACT:

Background

Cam morphology is associated with acetabular cartilage lesions and early-onset osteoarthritis in patients with femoroacetabular impingement syndrome. Here, we propose a novel iterative rabbit model of cam morphology to characterize the pathophysiology of femoroacetabular impingement-related cartilage lesions.

Methods

We described a repeatable method for establishing a New Zealand white rabbit model of cam morphology by interfering with the epiphyseal tubercle and evaluated the histological outcomes of acetabular cartilage lesions. Cam morphology and subchondral bone were evaluated by micro-CT scanning. The expression of anabolic and catabolic biomarkers of acetabular cartilage was investigated via western blotting and immunohistochemical staining. Chondrocyte apop

SUBMITTER: Li Z 

PROVIDER: S-EPMC12502403 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature