Differentiating network structures and sex differences of pain-related outcomes, analgesic opioid dosages, and psychosocial factors for postoperative management: a study of PAIN OUT registry in seven Asian regions.

ABSTRACT:

Background

Despite advancements in global healthcare, Asia lacks a systematic framework for postoperative pain-related symptoms, particularly in addressing pain identification/prevention and reporting sex differences. This study used network analysis to unravel the complex interplay of pain-related symptoms, analgesic opioid dosages, and psychosocial factors, with a particular focus on sex differences in the Asian population.

Methods

Utilizing anonymized data from 5,093 adult patients across seven Asian regions between 2018 and 2021 from the PAIN OUT registry, this study applied network analysis: 1) to map the relationships between analgesic opioid dosages and multidimensional pain-related symptoms and 2) to explore sex differences. This network analysis was performed based

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12502417 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature