Genomic landscape of cancer driver genes in Omani breast cancers: a pilot study.

ABSTRACT:

Background

The global rise in breast cancer (BC) incidence is mirrored in the Sultanate of Oman, where the median age of diagnosis is strikingly young at 47 years. This pilot study represents the first in the region to examine the genetic alterations of Omani BC biopsies and resected tumors and their correlations with patient characteristics using a targeted pan-cancer panel.

Methods

Utilizing the Oncomine Comprehensive Assay Plus, we profiled 40 BC biopsies alongside 22 matched post-neoadjuvant chemotherapy samples, identifying single-nucleotide variations (SNVs) and copy number variations (CNVs). Chi-Square and Fisher's Exact tests were used for categorical variables. In contrast, the Independent T-test and Levene test were used for continuous variables. Comparative analys

SUBMITTER: Al Dlali M 

PROVIDER: S-EPMC12502422 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature