Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease.

ABSTRACT:

Background

Obesity is thought to increase cardiovascular disease (CVD) risk partly through dyslipidemia. Yet, obesity's effects on dyslipidemia are not uniform. Understanding the shared genetic basis between obesity and lipid traits can provide insight into this heterogeneity and its implications for CVD risk.

Methods

We examined local genetic correlations between three lipid measures [high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), and triglycerides (TG)] and body mass index (BMI) using genome-wide association study summary statistics from European ancestry UK Biobank participants. We identified genomic loci with opposing genetic effects on obesity and dyslipidemia risk (protective BMI-lipid loci) and those with concordant directions f

SUBMITTER: Kim D 

PROVIDER: S-EPMC12502452 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature