Association of clonal haematopoiesis with heart failure incidence and outcomes: A systematic review and meta-analysis.

ABSTRACT:

Aims

Clonal haematopoiesis (CH) is recognized as a significant risk factor for various non-haematologic conditions, including cardiovascular diseases. However, recent studies examining its relationship with heart failure (HF) have reported conflicting findings. To address these inconsistencies, the present meta-analysis aimed to evaluate the association of CH with the incidence and clinical outcomes of HF.

Methods and results

MEDLINE, Cochrane Library and Scopus were searched until 12 December 2024. Triple-independent study selection, data extraction and quality assessment were performed. Evidence was pooled using three-level mixed-effects meta-analyses. Participants (n = 57 755) with CH had significantly greater risk of new-onset HF compared to the non-CH group (hazard rati

SUBMITTER: Karakasis P 

PROVIDER: S-EPMC12502460 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature