Factors influencing antithrombin activity following supplementation in sepsis-associated disseminated intravascular coagulation.

ABSTRACT:

Background

Antithrombin, a key regulator of the coagulation cascade, is often decreased in patients with sepsis-associated disseminated intravascular coagulation (DIC). Antithrombin is commonly supplemented when activity levels fall to 70% or below in Japan. While there is considerable interindividual variability in antithrombin activity following treatment, the factors contributing to this variability remain unclear. This study aims to identify the determinants of post-treatment antithrombin activity levels and to investigate the potential association between antithrombin activity and bleeding risk.

Methods

We conducted a retrospective analysis using data from the post-marketing surveillance of antithrombin concentrate in patients with sepsis-associated DIC. Changes in anti

SUBMITTER: Tanigawa T 

PROVIDER: S-EPMC12502486 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature