Exploring the pentraxin-3 as a prognostic biomarker in paraquat poisoning: a systematic-narrative hybrid review.

ABSTRACT:

Purpose

Paraquat is a commonly used pesticide that is highly toxic to humans and leads to fatal lung fibrosis upon consumption. Due to its rapid clearance from the bloodstream, there are no reliable biomarkers for the diagnosis and prognosis of paraquat intoxication. Pentraxin 3 (PTX3), an acute-phase inflammatory mediator, has emerged as a potential biomarker, particularly in the context of lung injury and fibrosis. This review aimed to assess the prognostic value of the level of PTX3 in predicting clinical outcomes in patients with paraquat poisoning and to evaluate the correlation between PTX3 levels and the severity of poisoning.

Methods

A comprehensive literature search was conducted using PubMed, MEDLINE (Ovid), EMBASE (Ovid), Web of Science, Scopus, CROSSREF, and Goog

SUBMITTER: Mathew D 

PROVIDER: S-EPMC12502491 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature