Sex differences in dementia risk: considering underlying medical conditions.

ABSTRACT:

Background

Underlying medical conditions may explain inconsistent reports of the association between sex and dementia risk. The current study aimed to explore the association between sex and the risk of incident dementia, considering a broad range of medical conditions.

Methods

This prospective national birth cohort study consisted of 53,224 members of a nonprofit health maintenance organization. Participants were born between 1922 and 1946 and entered the cohort on January 1, 2002, aged 55 to 80, without a dementia diagnosis. The cohort was followed up for 18 years to January 1, 2020. Dementia was ascertained based on medical diagnoses. Cox regression models were fitted to quantify the association between sex and the risk of incident dementia with hazard ratios (HR) and the

SUBMITTER: Rotstein A 

PROVIDER: S-EPMC12502507 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature