Increase of <i>Clostridioides difficile</i> PCR ribotype 002 infection with decreased disease severity in hospitalized patients in the Netherlands.

ABSTRACT: Clostridioides difficile PCR ribotype (RT) 002 is the second most prevalent RT in the Netherlands. In 2019, an increase in Clostridioides difficile infections (CDIs) due to clonal RT002 strains was reported in Ireland. In retrospect, a significant increase in the proportion of CDI due to RT002 was detected in the Netherlands between May 2017 and May 2018 (11.9% of 683 cases vs 6.5% of 865 in the previous year). Our aim was to analyze and characterize CDI due to RT002 over time and to assess whether RT002 isolates in the Netherlands were related to the Irish RT002 isolates.During the period from May 2009 to April 2021, Dutch patients with CDI due to RT002 showed less severe CDI (22%) in comparison with hypervirulent RTs (RT027, 29%, and RT078, 25%), similar to grouped data fro

SUBMITTER: Baktash A 

PROVIDER: S-EPMC12502521 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature