<i>Streptomyces</i> sp. BI87 from human gut: potent anticancer activities and divergence from known <i>Streptomyces</i> lineages.

ABSTRACT: Cancer is among the deadliest diseases with few truly curative therapies. Recent studies have shown that the human intestinal microbiota contains bacteria that exhibit potent suppressive effects on cancer or coordinate anticancer functions with the immune system. However, whether the peculiar anticancer trait was acquired stochastically by a strain of a non-anticancer bacterial species or an intrinsic property of a phylogenetic lineage of bacteria remained unclear. In this study, we compared a human gut isolate Streptomyces sp. BI87, which had highly effective anticancer activities, with the type strain of Streptomyces albidoflavus, DSM 40455^T, which was most closely related to BI87 among 30 type strains of the genus Streptomyces but did not show any detecta

SUBMITTER: Wang Y-H 

PROVIDER: S-EPMC12502529 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature