Sex-specific associations between insomnia symptoms and mental health among Chinese young adults and the modified effect of CRY2 gene DNA methylation.

ABSTRACT:

Background

The prevalence of insomnia and mental illness varies by sex. The mRNA expression level of the CRY gene in patients with insomnia is significantly decreased, and the expression level of the CRY2 gene is closely related to depression. However, sex differences in the link between insomnia and symptoms of anxiety, depression, and stress, as well as whether CRY2 gene DNA methylation can regulate this association, are not yet fully understood.

Objective

Investigate sex-specific differences in the associations between insomnia symptoms and symptoms of anxiety, depression, and stress among young adults. Furthermore, we explored whether the CRY2 clock DNA methylation moderates these relationships.

Methods

A total of 1100 participants from two Chinese universities pr

SUBMITTER: Fan M 

PROVIDER: S-EPMC12502542 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature