Deciphering metabolic reprogramming of immune cells within the tumor microenvironment.

ABSTRACT:

Background

Immunometabolic adaptations may induce tumor immune escape and immunotherapeutic resistance, representing crucial mechanisms in cancer progression. Understanding the metabolic rewiring of tumor-infiltrating immune cells as tumors advance could enhance current immune-oncology treatments.

Methods

In this study, we investigated metabolic heterogeneity in immune cells within both tumor and adjacent normal tissue using single-cell transcriptome profiling of colon cancer. We also utilized the MC38 colorectal cancer model, a commonly employed mouse tumor model, to assess the metabolic atlas of major immune cell populations in tumor and normal tissue.

Results

We examined the immunometabolic features in tumor tissue and adjacent normal tissue using public single-cel

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12502548 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature