Commensal <i>Escherichia coli</i> inhibits the growth and modulates the fitness, virulence, and antimicrobial resistance of <i>Salmonella</i> Heidelberg <i>in vitro</i>.

ABSTRACT: Nontyphoidal Salmonella (NTS) are major foodborne pathogens primarily transmitted to humans through contaminated poultry products. Increased antimicrobial resistance (AMR) in NTS, including Salmonella Heidelberg (SH), has recently become a public health issue. Current control measures are inadequate, emphasizing the need for novel approaches to mitigate NTS colonization in poultry and contamination of poultry products. We hypothesized that commensal Escherichia coli can reduce antibiotic-resistant NTS colonization in the chicken intestines by modulating the fitness, virulence, and AMR potential of Salmonella. To test this hypothesis, we co-cultured a commensal E. coli strain (EC47-1826) isolated from a commercial broiler chicken and an antibiotic-resistan

SUBMITTER: Khan YR 

PROVIDER: S-EPMC12502555 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature