Molecular characterization of colistin resistance in carbapenem-resistant <i>Klebsiella pneumoniae</i> from a tertiary hospital in China.

ABSTRACT: Colistin resistance in carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant global health challenge, as colistin remains the last-resort antibiotic for treating multidrug-resistant K. pneumoniae infections. This study aimed to investigate the prevalence and molecular mechanisms underlying colistin resistance in CRKP (Col^r-CRKP) isolates in Henan, China, from 2021 to 2024. The minimum inhibitory concentrations of colistin for 134 K. pneumoniae isolates were determined using the broth microdilution method. Whole-genome sequencing was performed using the Illumina platform to identify carbapenemase genes and sequence types (STs). Colistin resistance mechanisms were investigated, including mutations in two-component systems (pmrA/

SUBMITTER: Qi S 

PROVIDER: S-EPMC12502562 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature