Assessment of the 1,3-β-D-glucan test and the galactomannan antigen test in the detection of invasive fungal infections in patients with hematological diseases.

ABSTRACT: To evaluate the diagnostic performance of the 1,3-β-D-glucan (BDG) test and the galactomannan (GM) antigen test in invasive fungal infections (IFI) among hematologic patients and to explore an optimized diagnostic approach. A total of 294 consecutive patients with hematological diseases suspected of fungal infections were enrolled at Peking University People's Hospital from January 2020 to October 2023. IFI diagnosis referred to a composite reference standard (CRS), which combined both mycological and clinical evidence. Serum BDG (cut-off: 60 pg/mL) and GM (cut-off: 0.5) tests were analyzed. Of the 294 patients, 122 were classified as IFI-positive, including cases of invasive Aspergillosis (IA, n = 55), invasive Candidiasis (IC, n = 49), and other fungal infections (n

SUBMITTER: Wei Z 

PROVIDER: S-EPMC12502599 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature