The PI3K/AKT/mTOR Pathway and Oral Diseases: A Bibliometric Analysis From 2008 to 2025.

ABSTRACT:

Objectives

The phosphoinositide 3 kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway is a key therapeutic target for oral diseases. This study uses bibliometric analysis to identify research trends, knowledge gaps, and the development of PI3K/AKT/mTOR-targeted therapies.

Methods

A systematic literature search was conducted in March 2025 using the keywords "PI3K/AKT/mTOR" and "dental OR oral." Publication trends, highly cited studies, research hotspots, and emerging trends were analyzed. Comparative analyses of publication year, study design, and disease categories were performed between Asian and non-Asian cohorts.

Results

From 2008 to 2025, 119 studies were identified, with China, India, and Japan leading in publications and c

SUBMITTER: Gan Y 

PROVIDER: S-EPMC12502616 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature