The NagY antiterminator in <i>Enterococcus faecalis:</i> a novel regulatory mechanism and its impact on cell metabolism.

ABSTRACT: The Enterococcus genus is the most controversial group of lactic acid bacteria. While some strains are used as probiotics, other species, including Enterococcus faecalis, are responsible for health-related pathologies. Under conditions of infection, the N-acetylglucosamine metabolism of E. faecalis undergoes significant changes in expression, even more important than those of virulence factors. This metabolism is mediated by the nagY-nagE operon, which is regulated by the transcriptional antiterminator NagY. In this report, we focus on the regulatory mechanism of NagY and its impact on bacterial metabolism. We showed that NagY requires the interaction with the RNase III to achieve optimal induction of its own expression by cleaving the 5' untranslated region of

SUBMITTER: Soussan D 

PROVIDER: S-EPMC12502629 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature