Clinical and Microbiological Outcomes of Critically Ill Patients With Monomicrobial Versus Polymicrobial Bacterial Bloodstream Infections: A Retrospective Cohort Study.

ABSTRACT:

Background

The impact of polymicrobial bloodstream infections in critically ill patients is uncertain.

Methods

This observational cohort study included patients admitted to the ICU for ≥3d. We compared patients with monomicrobial versus polymicrobial (ie, ≥1 positive blood culture with ≥2 isolates) bloodstream infections. Inverse-probability weighting and covariate-adjusted generalized linear regression models were used to calculate adjusted differences in risks and means. The primary outcome was 90-day all-cause mortality from index culture. Secondary outcomes included 30-day all-cause mortality, microbiological failure, ECMO at 30 days, ARDS at 7 days, fever at 7 days, length of ICU and hospital stay. A separate analysis was performed excluding common skin commensals.

R

SUBMITTER: Jorda A 

PROVIDER: S-EPMC12502659 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature