A novel broad host range phage phiA85 displays a synergistic effect with antibiotics targeting carbapenem-resistant <i>Klebsiella pneumoniae</i>.

ABSTRACT: Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a major public health threat worldwide due to the limited treatment options available. There is an urgent need to explore new treatment strategies. Although phages are considered to be an effective treatment, most characterized Klebsiella phages demonstrate narrow host ranges restricted to specific capsular types (KL types), thereby limiting their clinical applicability. In the present study, we isolated a novel broad host range phage, phiA85, with high lytic activity and biofilm inhibitory efficacy against host strains of 13 different KL types and 12 ST types. Among these host strains, six strains were identified as multidrug-resistant (MDR)-CRKP covering five different KL types. To further optimize phage therapy, this

SUBMITTER: Li Z 

PROVIDER: S-EPMC12502666 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature