Multi-omics analysis reveals the host-microbe interactions on the dysbiosis of tissue microbiota in male genital lichen sclerosus-induced urethral strictures.

ABSTRACT: Male genital lichen sclerosus-induced urethral stricture is a chronic inflammatory disease with significant microbiota dysbiosis. However, dysbiosis inside lesion tissue and its correlation with gene expression in male genital lichen sclerosus (MGLSc) remain elusive. This study investigated the influence of host-microbe interactions on dysbiosis and differential gene expression in MGLSc. Microbiome and transcriptome sequencing were conducted using prepuce samples from 27 MGLSc patients and 17 controls. We also performed immunohistochemistry staining of bacterial markers on prepuce tissue from two cohorts. Furthermore, potential risk factor information available from the MGLSc clinical data was collected and correlated with the differential microbiota. Unclassified Muribaculaceae and Esc

SUBMITTER: Yu Z 

PROVIDER: S-EPMC12502673 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature