Diagnostic and prognostic roles of interferon-λ1 and interferon-λ3 in bronchoalveolar lavage fluid and plasma in non-neutropenic patients with invasive pulmonary aspergillosis.

ABSTRACT: This study aims to evaluate the diagnostic and prognostic value of interferon (IFN)-λ1 and IFN-λ3 levels in bronchoalveolar lavage fluid (BALF) and plasma in non-neutropenic invasive pulmonary aspergillosis (IPA) patients. A total of 481 patients suspected of IPA were enrolled (169 IPA cases and 312 non-IPA cases) in this study. BALF and plasma samples were collected, and IFN-λ1 and IFN-λ3 levels were measured using an enzyme-linked immunosorbent assay. In IPA patients, BALF IFN-λ1 and IFN-λ3 levels were significantly higher than in non-IPA patients (IFN-λ1: 284.60 [229.12, 357.99] pg/mL vs. 189.50 [140.00, 233.69] pg/mL, P < 0.0001; IFN-λ3: 189.70 [94.94, 271.79] pg/mL vs. 78.15 [36.54, 149.14] pg/mL, P < 0.0001). However, no significant differences were observed in plasma I

SUBMITTER: Sun C 

PROVIDER: S-EPMC12502686 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature