Humoral response dynamics following inactivated SARS-CoV-2 vaccination and their association with subsequent infection and symptoms in individuals with and without prior SARS-CoV-2 infection: evidence from Sichuan Province, China.

ABSTRACT: This study integrated multisource longitudinal data with trajectory modeling to delineate the heterogeneity of humoral immune dynamics induced by inactivated SARS-CoV-2 vaccinations and their clinical implications for subsequent SARS-CoV-2 infection outcomes in 205 individuals from Sichuan Province, China. We found that preexisting infection status served as the dominant stratifier of antibody trajectory divergence across the cohort. Additionally, among individuals without prior infection before the vaccine cohort, we identified five distinct immune response patterns with clinical implications. An age-associated "minimal response" subtype was associated with an increased risk of prolonged recovery time, sore throat, and limb pain in subsequent infections. In contrast, a subtype characteriz

SUBMITTER: Yu Y 

PROVIDER: S-EPMC12502705 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature