Profiles of oral microbiota and metabolites in periodontitis and benign prostatic hyperplasia patients: a pilot study.

ABSTRACT: Emerging evidence suggests a potential link between periodontitis and benign prostatic hyperplasia (BPH). We have demonstrated that experimental periodontitis and the periodontal pathogen Porphyromonas gingivalis exacerbate the progression of BPH. In this study, we focused on the characteristics and alterations of the oral microbiome and metabolites in patients with BPH and those with both BPH and periodontitis. Forty-eight men aged 40 to 60 years were recruited and divided into four groups: healthy controls, periodontitis, BPH, and periodontitis combined with BPH (P-BPH). Gingival crevicular fluid samples were collected for 16S rRNA sequencing and mass spectrometry analysis. The species composition diversity among the four groups showed significant differences. Compared with the he

SUBMITTER: Zhu C 

PROVIDER: S-EPMC12502708 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature