Comprehensive genomic analysis of antibiotic resistance plasmids in animal-associated <i>Staphylococcus aureus</i> in France.

ABSTRACT: In Staphylococcus aureus, an animal pathogen and zoonotic agent, plasmids play a pivotal role in the acquisition and spread of antibiotic resistance genes (ARGs). This study investigated the plasmid content of 329 S. aureus isolates from livestock and companion animals collected in France between 2010 and 2021. Plasmids (n = 211) were identified from 139 isolates. The major families identified-rep7a, rep20, and rep10-were associated with specific resistance genes (str, cat, blaZ, erm(C)) and exhibited widespread horizontal transfer across different S. aureus sequence types (STs) and animal hosts. In temporal analysis, the rep7a/str and rep7a/cat plasmids circulating in horses were progr

SUBMITTER: Contarin R 

PROVIDER: S-EPMC12502713 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature