A role for Dps ferritin activity in long-term survival of <i>Escherichia coli</i>.

ABSTRACT: Escherichia coli expresses three ferritins that store acquired iron by oxidizing soluble Fe(II) to insoluble Fe(III), which can accumulate and later be utilized in cellular processes. Although bacterioferritin (Bfr) and ferritin (FtnA) sequester more Fe(III) atoms per multimeric complex, the abundance of the DNA-binding protein from starved cells (Dps), coupled with its preference for hydrogen peroxide as an oxidant in its ferroxidase activity, makes it a fundamental component in iron homeostasis and long-term stationary phase (LTSP) survival. To investigate the temporal role and mechanisms of action of Dps in parallel with the other ferritins, growth yield, survival, competitive fitness, and siderophore assays were performed under different conditions of iron availability. dps</

SUBMITTER: Serebnitskiy Z 

PROVIDER: S-EPMC12502760 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature