Molecular epidemiology and pretreatment drug resistance of HIV-1 among newly diagnosed individuals in Nanning City, Guangxi, China.

ABSTRACT: Emerging pretreatment drug resistance (PDR) significantly reduces the effectiveness of HIV antiretroviral therapy (ART). This study assessed the prevalence, associated factors, and transmission networks of PDR among newly diagnosed, ART-naïve individuals in Guangxi, China, from 2019 to 2022. A cross-sectional study was conducted between 2019 and 2022 in Nanning, Guangxi, involving 1,260 newly diagnosed, ART-naïve individuals with HIV. PDR levels and mutations were identified using the Stanford HIV Drug Resistance Database. Multivariable logistic regression models were employed to identify factors associated with PDR and to cluster the molecular network. A total of 1,048 eligible pol sequences were analyzed. The overall prevalence of PDR was 8.4%, with non-nucleoside reverse transcriptase i

SUBMITTER: Huang T 

PROVIDER: S-EPMC12502766 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature