Impact of obesity on the gut microbiome and inflammatory markers during SIV infection and antiretroviral therapy.

ABSTRACT: Dysbiosis and impaired gut barrier integrity contribute to chronic immune activation associated with both obesity and HIV infection. Given the increased incidence of obesity in people living with HIV, we explored the impact of obesity on the gut microbiome and microbial translocation (MT) biomarkers during HIV infection and antiretroviral therapy (ART). Lean and obese rhesus macaques were infected with simian immunodeficiency virus (SIV) and subsequently treated with ART. Obese animals exhibited higher initial MT and inflammation biomarkers that remained constant throughout the study, while lean animals exhibited significant increases in these biomarkers that approached levels observed in obese animals. Lean and obese animals exhibited similar observed amplicon sequence variants (ASVs) at

SUBMITTER: McGuire CM 

PROVIDER: S-EPMC12502777 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature