Gastric microbiota transplantation enhanced the eradication of refractory <i>Helicobacter pylori</i> infection by modulating the gastric microbiota: a pilot study.

ABSTRACT: Dysbiosis of the gastric microecology is implicated in various gastric diseases, with Helicobacter pylori (H. pylori) infection serving as a pivotal factor influencing the gastric microecological balance and vice versa. In this study, we investigated the novel effects of gastric microbiota transplantation (GMT) on gastric microecology and the potential of this treatment to enhance H. pylori eradication. We performed a metagenomic analysis of the microecological systems across different regions of the stomach, including the gastric fluid (GF), the gastric mucus layer (GML), and the gastric mucosa (GM). We initiated a clinical GMT intervention by transplanting microbial communities from healthy individuals' GML into patients exhibiting refractory H. pylori infecti

SUBMITTER: Li J 

PROVIDER: S-EPMC12502787 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature