Serum cytokine panels in pediatric clinical practice.

ABSTRACT:

Background

Cytokines are soluble signaling proteins that regulate inflammation and coordinate immune responses. Serum cytokine panels are increasingly used in medical practice, yet our understanding of cytokines as biomarkers for disease remains limited.

Objective

We sought to analyze real-world single-center use of a multiplexed cytokine panel, correlate its results with diagnosis and severity, and explore its use in pediatric practice.

Methods

A multiplexed cytokine panel, able to return same-day results, was implemented in April 2020 at the Children's Hospital of Philadelphia (Philadelphia, Pa) and its performance was validated for clinical use. Coded patient data were collected using the REDCap database, and correlations between cytokine levels and outcomes of int

SUBMITTER: Gallo PM 

PROVIDER: S-EPMC12502881 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature