Farnesoid X Receptor Agonist Tropifexor Improves Intestinal Defense Response and Epithelial Barrier Function in Neonatal Piglets Receiving Parenteral Nutrition.

ABSTRACT: Long-term parenteral nutrition (PN) can lead to liver and intestinal injury in neonates, but effective prevention strategies are limited. Our previous research demonstrated that activation of farnesoid X receptor (FXR) signaling with tropifexor (TXR) could mitigate PN-induced liver damage in neonatal piglets, but its effect on intestinal injury remains to be addressed. In this study, two-day-old Bama minipigs were randomly allocated into three groups (n = 6/group): EN (receiving enteral nutrition, serving as a control), PN, and PT (PN + TXR treatment). Consequently, TXR treatment significantly mitigated PN-induced intestinal injury, including villus atrophy, hyper-permeability, and impaired defense responses. Transcriptomic profiling identified 1188 differentially expressed genes (DEGs) in

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC12502888 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature