Exploring weak noncovalent interactions in a few halo-substituted quinolones.

ABSTRACT: Crystal engineering utilizing weak interactions provides a real solution to increase the potential of active pharmaceutical ingredients (APIs). Quinolone derivatives represent one of the most widely used molecules, having potential applications in medical fields as antibacterials and antimalarials. This study addresses a few systematically designed and crystallographically characterized chloro- and fluoroquinolones in order to investigate the weak interactions leading to the formation of supramolecular assemblies. The interactions in crystal packing are discussed in terms of N-H⋯X, C-H⋯X (X = F, Cl), π⋯π, C-H⋯π, and lone pair (lp)⋯π interactions, along with unique homo- and hetero-halogen bonding, viz. F⋯F, F⋯Cl, Cl⋯O, and C-F⋯π, as well as C-H⋯H-C interactions. N-Ethyl deriv

SUBMITTER: Kumar S 

PROVIDER: S-EPMC12502904 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature