Optimal Tranexamic Acid Dosing for Adolescent Idiopathic Scoliosis Surgery: A Frequentist Network Meta-Analysis.

ABSTRACT:

Study design

Systematic review and network meta-analysis (NMA).

Objective

This NMA evaluates the clinical efficacy and safety of various doses of Tranexamic acid (TXA) for adolescent idiopathic scoliosis (AIS) instrumentation.

Summary of background data

TXA is an antifibrinolytic agent widely used in spine surgery. However, the optimal TXA dose remains unclear, especially for younger patients.

Methods

We performed a systematic search across PubMed, Scopus, Web of Science, and the Cochrane Library up to March 2025. We included studies that compared different TXA doses or patients without TXA in AIS surgery. We evaluated five TXA doses: TXA 0 (control without TXA); TXA 1 (10 mg/kg bolus + 1 mg/kg/hr infusion); TXA 2 (15-20 mg/kg bolus + 1-10 mg/kg/hr infusion); T

SUBMITTER: Lajczak P 

PROVIDER: S-EPMC12502950 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature