High energy consumption characterizes abnormal brain state transitions in temporal lobe epilepsy.

ABSTRACT: Temporal lobe epilepsy (TLE) patients experience shifts between non-seizing and seizing brain states, but the structural networks underlying these transitions remain undefined and poorly characterized. We detected dynamic brain states in resting-state fMRI and constructed linked structural networks utilizing multi-shell diffusion-weighted MR data. Leveraging network control theory, we interrogated the structural data for all possible brain state transitions, identifying those requiring abnormal levels of transition energy (low or high) in TLE compared to matched healthy participants (n's = 25). Results revealed three transitions requiring significantly higher energy in TLE; no abnormally low-energy transitions were observed. In HPs, transitions relied on mediator regions that did not belon

SUBMITTER: Javidi SS 

PROVIDER: S-EPMC12502986 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature