Actinomycetoquinones A-E, Anthraquinone-γ-Pyrones Discovered from Marine-Derived <i>Actinomycetospora</i> sp. Bacterium.

ABSTRACT: Facilitated by LC-MS-PCA metabolomics methods and effective molecular networking for strain prioritization and dereplication, five new anthraquinone-γ-pyrones, actinomycetoquinones A-E (1-5), were isolated from a marine-derived Actinomycetospora sp. bacterium. The structures of 1-5 were elucidated by analysis of their HRMS and NMR spectroscopic data. The absolute configuration of 1 was unequivocally determined by single-crystal X-ray diffraction analysis using Cu Kα radiation. Actinomycetoquinone C exhibited antibacterial activity against methicillin-resistant S. aureus (MRSA) and E. coli with MIC values of 1 and 4 μg/mL, respectively.

SUBMITTER: Zhang F 

PROVIDER: S-EPMC12503092 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature