Strain-level variation controls nutrient niche occupancy by health-associated <i>Anaerostipes hadrus</i>.

ABSTRACT: Nutrient niche access by the gut microbiota impacts community assembly and dynamics, the production of host-benefiting short-chain fatty acids (SCFAs), and pathogen inhibition through colonization resistance. Furthermore, deciphering if and how niche access varies on a strain level will be important as individual strains of gut microbes are selected for inclusion in new live biotherapeutic products. Despite this, for many gut anaerobes, nutrient niche occupancy and impacts of strain variation remain unknown. Here, we examined nutrient niches of Anaerostipes hadrus (AH), a butyrate-producing member of the Lachnospiraceae family. We found that AH isolates encode a carbohydrate metabolism gene repertoire that is distinct from other Lachnospiraceae. Furthermore, tes

SUBMITTER: Herold L 

PROVIDER: S-EPMC12503163 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature